Do you have unexplained,
lingering limb pain following
an injury or surgery?

You may have Complex Regional Pain Syndrome (CRPS).

About CRPS

Complex Regional Pain Syndrome (CRPS) is a chronic condition that causes intense pain - usually in the arms, hands, legs, or feet. CRPS often develops after an injury or trauma (such as an ankle fracture, wrist fracture, or surgery). However, the pain associated with CRPS is usually much greater than the original injury.

Symptoms of CRPS include:

  • Intense burning pain
  • Changes in skin temperature, color, or texture
  • Extreme skin sensitivity
  • Swelling or stiffness in the affected area

CRPS is considered one of the most painful types of chronic pain, and it can take a major toll on one’s quality of life.

About the Study

Doctors at select centers in the U.S., U.K.,Canada and Australia are currently accepting participants for the CREATE-1 Clinical Study. The study is for an investigational oral medication that may help improve CRPS symptoms. If you suspect you have CRPS, or have been diagnosed with CRPS within the past 6 months, this study may be right for you.

If you can answer “Yes” to these questions, you may be eligible for the CREATE-1 Clinical Study:

  • Is your pain in either one upper limb (arm, wrist or hand), or one lower limb (leg, ankle or foot)?
  • Can your pain be linked to an injury, trauma, or surgery?
  • Are you able to attend required visits at your local study center over a 6 - 7 month period?

If you qualify and choose to join the study, you will receive all study-related care at no cost. This includes all study medications, as well as any visits associated with the study. You may also be compensated for your time and travel to attend study visits.



Frequent Questions
Clinical studies (also known as clinical trials) are used to learn about the safety and effectiveness of possible new medications, medical devices, and medical procedures. Although there are many types of clinical trials, all must conform to strict rules set by country-specific regulatory authorities. These rules help protect the rights and safety of those who volunteer to take part in clinical trials.
The study is being conducted by trained, qualified, licensed physicians and medical specialists.
If you choose to join the study, you will receive all study-related care at no cost. This includes all study medications, as well as any visits associated with the study. You may also be compensated for your time and travel to attend study visits.
The study lasts approximately 6 - 7 months. During this time, you will be asked to meet with your local study doctor up to 13 times.
As with all clinical studies, your participation is completely voluntary and you may leave the study at any time. This will not affect your medical care or relationship with any of your doctors.
To see if you might qualify for the study, the next step is taking the pre-screening questionnaire. Please click here to get started.

See If You Qualify

If you suspect you have Complex Regional Pain Syndrome (CRPS), or have been diagnosed with CRPS within the past 6 months, you may be interested in the CREATE-1 Clinical Study. To see if you might qualify, and to get connected directly with your local study center to learn more, please take the questionnaire below.